Synthesis of Enantioselective Chiral NMR Shift Reagents

Abstract

Calix[4]resorcarenes are effective chiral NMR shift reagents for many types of molecules. The synthesis of calix[4]resorcarenes was begun as according to previous literature. Over the course of the experiment, many procedural modifications were made to enhance the yield of the final product. The yield of the product still remains extremely low, and more modifications need to be made to further enhance the yield.