Determination of Enantiomeric Composition via the Supramolecular Interactions of Rhodamine B or Cyclodextrins
Abstract
Different enantiomers can have disparate effects in biological systems. A majority of
prescription drugs are chiral, which is why there is a demand to develop facile and cost-effective
methods to measure enantiomeric composition. The ability to measure enantiomeric
composition, however, is difficult because of the identical physical properties enantiomers
possess in achiral environments. Two novel methods utilizing supramolecular sensors are
outlined. The first method describes the synthesis of a chiral rhodamine B derivative with the
potential to function as an enantioselective sensor. The second method monitors the change in
the capacitance of a microsensor coated with a modified γ-cyclodextrin in order to determine
enantiomer composition. Both methods demonstrate the potential of supramolecular systems in
regards to chiral sensing.
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