Examining the Mechanics of Chiral Recognition in Phosphotriesterase and Molecular Micelles
Abstract
Chiral recognition plays an important role in the many places including chiral
chromatography and the biological world where many enzymes are enantioselective.
Understanding how molecular micelles and enzymes like phosphotriesterase are able to
detect and distinguish isomers can help explain how chiral drugs or compounds are
consumed within the body. The binding of 1,1'-binaphthyl-2,2'-diyl hydrogen phosphate
to a molecular micelle containing a dipeptide head group was explored using NMR
spectroscopy. Similarly, enzyme kinetics were used to study how site-target mutagenesis
affected the enzymatic site of phosphotriesterase. In both cases, it was found that a
macromolecules ability to detect chirality changed when the residues within the binding
pocket of each changed.
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Measuring the Correlation Times of Molecules Bound to Chiral Molecular Micelles
Hamerly, Tim (2010-09-09)NMR spectroscopy was used to determine the correlation times of 1,1'- binaphthyl-2,2'-diyl hydrogen phosphate (BNP) protons when bound to molecular micelles. These molecular micelles contained a dipeptide head group composed ... -
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