Investigation of Interactions between β‐blocker Drugs and Polymers via NMR Diffusion Experiments

Abstract

NMR spectroscopy was used to study the binding of β-blockers to chiral polymers. In order to effectively separate these mixtures, the chiral interactions need to be well understood. Chiral polymers were used to study binding constants and free energy values for each analyte. The Propranolol had the strongest interaction with each polymer while Atenolol had the weakest. Correlations were seen between NMR association constants and chromatographic retention times as well as between the NMR free energies of binding and chiral selectivities. It was also concluded the polymer forms a chiral pocket with which the analytes interact