• Login
    View Item 
    •   DSpace Home
    • Scholarship
    • Chemistry Department
    • Chemistry Senior Theses
    • View Item
    •   DSpace Home
    • Scholarship
    • Chemistry Department
    • Chemistry Senior Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Synthesis of Novel Topopyrones and Evaluation of Their Topoisomerase Poisoning Activity

    • File:Synthesis of Novel Topopyrones and Evaluation of Their Topoisomerase Poisoning Activity.pdf
      Show File
      MIME type:application/pdf
      File Size:0.7 Mb

      Synthesis of Novel Topopyrones and Evaluation of Their Topoisomerase Poisoning Activity.pdf

      View/Open
    Thumbnail
    View/Open
    Synthesis of Novel Topopyrone... (0.7 Mb)

    Date
    2013-05-23
    Author
    Seiler, Grant
    Metadata
    Show full item record
    Abstract
    The topopyrones are a class of polycyclic molecules which act as topoisomerase poisons. Several novel derivatives have been synthesized, highlighting interesting ring formation reactions. These derivatives were tested for topoisomerase poisoning activity in vitro and compared quantitatively. Results have shed light on the relationship between structure and function in these molecules. The positioning of a halide substituent in linear and angular topopyrones has different effects on the activity of each group of molecules. In addition, it was shown that phenolic groups cause the compounds to act as poisons better than methoxy substituents. The new information found here may serve as a basis for developing more potent topopyrones, and also adds to the synthetic organic chemist’s list of techniques.
    Collections
    • Chemistry Senior Theses

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister
    Carthage College ©2015
    Contact Us | Send Feedback